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HFE gene mutations lead not only to enhanced iron uptake and its increased plasma concentrations, but also to progressive iron deposition in the cytoplasm of parenchymal cells of various organs and tissues (particularly hepatocytes, pancreatic cells, cardiomyocytes, skin, joints, and other organs), causing deleterious complications with multi-organ damage years later if left untreated [12,13]
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Studies show this is because oral tablets are absorbed by the digestive system, causing the medication to be distributed slowly throughout the body, reducing its targeting ability and effectiveness